WebHere, we aimed to investigate the effects of recombinant BRI2 ectodomain (rBRI276-266) on Aβ aggregation and on important molecular pathways involved in early stages of AD, including the unfolded protein response (UPR), phosphorylation and truncation of tau, as well as apoptosis. WebSep 4, 2024 · BRI2 phosphorylation promotes BRI2 processing increasing the levels of the proteolytic processing fragments that can further act as neuritogenic …
Wild-type and mutant (Y687E and Y687F) APP-GFP intracellular …
WebDownload scientific diagram The rate of cell surface expression/appearance/transport of BRI2 is reduced in the absence of N-glycosylation. Wild-type mycBRI2 or mycBRI2/ N170A was expressed in ... WebJan 1, 2016 · One can therefore conclude that BRI2 phosphorylation is a key event capable of modulating the number of neuritis, as well as the length of these processes in … cdc how to stay healthy
BRI2 and BRI3 are functionally distinct phosphoproteins
WebFeb 13, 2013 · Phosphorylation-dependent anti-tau Abs showed the presence of tau-immunopositive deposits in both nerve (C, neurons of the frontal cortex) and glial (D, … WebMar 13, 2024 · Importantly, changes in Notch expression can alter STAT3 phosphorylation and activity, ... FDD appears to be the result of a major frameshift mutation in the BRI2 gene that ultimately produces an abnormal ADan with amyloid subunits, forming cerebrovascular-associated plaques and neurofibrillary tangles . WebFeb 1, 2024 · BRI2 is a ubiquitously expressed type-II transmembrane phosphoprotein. BRI2 undergoes proteolytic processing into secreted fragments and during the maturation process it suffers... cdc how to stay healthy around pets