WebWhile carboplatin is substantially less ototoxic than cisplatin, both can lead to serious hearing loss requiring the use of assistive listening technology, preferential classroom seating, additional educational resources, and … WebCarboplatin is also known to be ototoxic. Environmental chemicals have long been implicated in ototoxicity. Little research has been done to substantiate their precise …

Ototoxicity - The American Academy of Audiology

WebSep 21, 2016 · Ototoxicity affects the inner ear, which is essential in both hearing and balance. High-dose carboplatin can also induce auditory dysfunction with a clinical picture that is largely the same as that after cisplatin therapy. 9, 10 Auditory function must be monitored carefully because the toxicity can become disabling. WebCarboplatin is more myelotoxic than cisplatin. Mechanism of action Like cisplatin, carboplatin works as an ‘atypical’ alkylator, binding and cross-linking DNA, which leads to DNA strand breakage during replication. Pharmacokinetics/metabolism Intravenous carboplatin is rapidly cleared by the kidneys, with a 2.5 h half-life. radio online luisteren nl

Ototoxicity: A Challenge in Diagnosis and Treatment - PMC

WebAug 1, 1993 · Although carboplatin is substantially less ototoxic than cisplatin in humans many other species, in the chinchilla, it produces an unusual pattern of ototoxic damage … WebAug 31, 2016 · Ototoxicity poses a major problem to the cancer patient, as the quality of life after receiving cisplatin chemotherapy may be negatively affected due to hearing loss, resulting in social, emotional, and vocational difficulties, as effective communication is … WebMonitoring carboplatin ototoxicity with distortion-product otoacoustic emissions in children with retinoblastoma Mean distortion-product otoacoustic emission levels at most frequencies were not changed following 3-4 courses of carboplatin chemotherapy in children with retinoblastoma. cute halle edita elvira