Chondrocyte thrombospondin
WebOct 11, 2011 · Thrombospondin-1 is a known chondrocyte-binding protein , whereas the other four cell adhesion proteins were either entirely novel cartilage constituents …
Chondrocyte thrombospondin
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WebIntroduction. Bone is a hard mineralized tissue whose structure and function are maintained through homeostatic load-adaptive remodeling, resulting in a sophisticated bone microarchitecture to meet mechanical demands 1.Joints are structures where adjacent bones or bones and cartilage connect with each other, providing stability and flexibility to … WebDec 2, 2015 · Chen FH, Thomas AO, Hecht JT, Goldring MB, Lawler J. (2005) Cartilage oligomeric matrix protein/thrombospondin 5 supports chondrocyte attachment through interaction with integrins. J Biol Chem 280: 32655–32661. pmid:16051604 . View Article PubMed/NCBI Google Scholar 31.
WebOct 2, 2012 · Secretome analysis of chondroitin sulfate-treated chondrocytes reveals anti-angiogenic, anti-inflammatory and anti-catabolic properties We have generated a quantitative profile of chondrocyte extracellular protein changes driven by CS in the presence of IL-1β. WebIn this study, TNF-α-stimulated porcine and human chondrocyte models were used to investigate the inhibitory effects of Cm-02 and Ck-02 on the molecular mechanisms underlying the anti-OA effects. TNF-α was used to stimulate porcine and human chondrocytes to mimic immunomodulatory potency in-vitro.
WebSep 29, 2016 · We evaluated the role of the CXCL12/CXCR4 (C-X-C motif chemokine ligand 12/C-X-C chemokine receptor type 4) axis in aggrecanase-mediated cartilage degradation, and explored the underlying mechanism in a post-traumatic osteoarthritis rat model. Expression of CXCL12/CXCR4 and ADAMTS-5 was analyzed in the knees of … Webchondrocyte: the major type of cell found in cartilage. Generally encased in a cartilage lacuna. chondroitin sulfate: a sulfated sugar with 40 to 60 repeating units of N -acetylgalactosamine and glucuronic acid, part of the glycosaminoglycan seen in cartilage.
WebMar 31, 2024 · Some of the most widely used surgical approaches that aim to repair chondral or osteochondral defects of the knee include microfracture and osteotomy. 10,41 Although advanced cell therapy approaches such as autologous chondrocyte implantation (ACI) have been highlighted as more efficacious and cost-effective for repair of chondral …
WebSep 23, 2005 · Abstract Cartilage oligomeric matrix protein/thrombospondin 5 (COMP/TSP5) is a major component of the extracellular matrix of the musculoskeletal … scaller live and doWebOct 11, 2011 · Thrombospondin-1 is a known chondrocyte-binding protein , whereas the other four cell adhesion proteins were either entirely novel cartilage constituents (tenascin X and emilin-1) or have never been described in post-natal cartilage (coiled-coil domain-containing protein 80/Urb and vitrin). scallen agencyWebJun 26, 2024 · Thrombospondin-1 (TSP-1) is a multifunctional matricellular protein mediating various cell-to-cell and cell-to-matrix … say her name movement 2020WebFeb 20, 2024 · Thrombospondin (TSP)‑1 and TSP‑2 are matricellular proteins in the extracellular matrix (ECM), which serve a significant role in the pathological processes of various cardiovascular diseases (CVDs). say her name movement essayWebNational Center for Biotechnology Information say her name jennifer packerWebA disintegrin and metalloproteinase (ADAM) family members with proteolytic activity may play roles in chondrocyte biology and OA. While regulation of both MMPs and ADAMTS … scalley reading bates hansen \\u0026 rasmussen p.cWebApr 14, 2024 · These growth factors regulate critical chondrocyte reparative functions by distinct and overlapping signal transduction pathways. ... and measuring the expression of A disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS)-4, ADAMTS-5, matrix metalloproteinase-3 (MMP)-3, MMP-13, and interleukin 6 (IL-6). Unexpectedly, the ... scallawags/waynesville nc