Cimetidine and theophylline drug interaction
WebDrug Interactions: What You Need to Know By Evan Starkman Medically Reviewed by Joshua Conrad, PharmD What Are Drug Interactions? What Are the 3 Types of Drug … WebThe tablet drug load (10.5–19.5 mg) of theophylline (2.25 mg increments) and cimetidine (3 mg increments) could easily be differentiated using univariate analyses.
Cimetidine and theophylline drug interaction
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WebFeb 1, 1983 · The effects of cimetidine on the pharmacokinetics of theophylline were studied in seven healthy subjects at steady state after oral dosing. Aminophylline (200 mg) was administered every six hours for three days (AX then aminophylline (200 mg) and cimetidine (300 mg) were administered every six hours for seven days (A-CX Multiple … WebSee the list of drugs that interact with Theophylline. Includes information on severity of interaction and the level of evidence for it. ... Drug interaction information. Severe interactions are highlighted with a red marker. ... Cimetidine increases the concentration of Theophylline. Manufacturer advises adjust dose. Severity: Severe. Evidence ...
WebAfter intravenous administration of cimetidine, the majority of the parent drug (58-77%) is eliminated unchanged in the urine. 2,7 Cimetidine’s primary metabolite is cimetidine sulfoxide and represents an estimated … WebIn summary, cimetidine is a potent inhibitor of liver microsomal activity, which may also decrease hepatic blood flow. Other effects of the drug include inhibition of gastric secretion and intrinsic toxic properties. These effects, combined with the common use of cimetidine in clinical practice, make the risk of adverse drug interactions a ...
WebDrug Interactions Cytochrome P450 Inhibition Strong and Moderate Inhibitors of CYP3A4 or CYP2D6 The effects of ketoconazole (a strong inhibitor of CYP3A4) at 400 mg once daily for 5 days on the pharmacokinetics of a single tamsulosin hydrochloride capsule 0.4 mg dose was investigated in 24 healthy volunteers (age range 23 to 47 years). WebTheophylline comes as an extended-release (long-acting) tablet, extended-release capsule, and a solution (liquid) to take by mouth. It usually is taken every 6, 8, 12, or 24 hours. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.
WebThis interaction may be worse if you have heart failure, liver disease, kidney disease, or are on large doses of a theophylline derivative.Your healthcare professionals may already be aware of ...
WebApr 22, 2024 · Adult dosage (ages 18–59 years) The usual starting dose is 300–400 mg per day. After 3 days, your dose may be increased to 400–600 mg per day if you don’t have any side effects. After 3 ... lafayette spay and neuter clinicWebCimetidine, 1,200 mg/day, significantly decreased theophylline clearance by 36% (range, 22% to 49%) and increased the mean elimination half-life from 5.7 hours … lafayette shuttle to indy airportWebBlood in your stools (black or tarry stools) or if you have blood in your vomit. Kidney disease. Liver disease. Pain or trouble trying to swallow food. An unusual or allergic reaction to … lafayette shutters exteriorWebSearch for drug interactions with our API. Drug Allergy. ... non-bronchodilator prophylactic effects). Mechanism of action. Theophylline relaxes the smooth muscle of the bronchial airways and pulmonary … lafayette serious injury attorneysWebCimetidine-theophylline interaction: effects of age and cimetidine dose. Influences of cimetidine dose and age on the cimetidine-theophylline interaction were evaluated. … lafayette sports networkWebJan 11, 2024 · Coadministration with drugs that decrease theophylline clearance (eg, cimetidine, ciprofloxacin, and erythromycin and other macrolides): 0.2-0.3 mg/kg/hr IV or orally (extended release) ... Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this drug, tell your doctor or pharmacist of all the … re newspaper\u0027shttp://origin-www.webmd.com/drugs/2/drug-14245/thsc-cimetidine-oral/details/list-interaction-details/dmid-62/dmtitle-cimetidine-theophylline-derivatives/intrtype-drug lafayette shutters indiana