Extra-hepatic thyroid receptor activation
WebDec 3, 2024 · Activation of thyroid hormone receptor β (THRβ) has shown beneficial effects on metabolic alterations, including non-alcoholic fatty liver disease (NAFLD). … WebOct 1, 2024 · New molecules with very high thyroid hormone receptor (TR)-β affinity and hepatic selectivity have been developed. However, the safety of these potent molecules must be carefully assessed in humans, as it is still unclear whether the failure of eprotirome was due to molecule- or class-related adverse effects.
Extra-hepatic thyroid receptor activation
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WebSep 4, 2012 · The mechanism of thyroid hormone action has been informed by these clinical observations as well as by animal models and has influenced the way we view the role of local ligand availability; tissue and cell-specific thyroid hormone transporters, corepressors, and coactivators; thyroid hormone receptor (TR) isoform–specific action; … WebDec 15, 2024 · One proposed mode of action (MoA) for hypothyroxinemia consists of the activation of the aryl hydrocarbon (AhR), constitutive androstane (CAR) and/or pregnane X (PXR) nuclear receptors in the liver, which increases metabolism and biliary elimination of thyroxine (T4) through induction of xenobiotic metabolizing enzymes.
WebJun 2, 2024 · Thyroid hormone/thyroid hormone receptor (TH/TR) axis is characterized by TH with the assistance of plasma membrane transporters to combine with TR and mediate biological activities. Growing evidence … WebEnter the email address you signed up with and we'll email you a reset link.
WebMar 3, 2024 · Activation of hepatic thyroid hormone receptor β (THR‐β) is associated with systemic lipid lowering, increased bile acid synthesis, and fat oxidation. In patients with … WebAug 30, 2024 · TRα can stimulate both proliferation and differentiation through β-catenin, while TRβ shows antiproliferative effects in cancer cells and is a differentiation factor. …
WebMar 3, 2024 · Activation of hepatic thyroid hormone receptor β (THR-β) is associated with systemic lipid lowering, increased bile acid synthesis, …
WebThe observation that most of the desired therapeutic effects of T3 in the liver are mediated by the activation of the isoform β of THRs and that THR activation in extrahepatic tissues leads to altered cardiovascular … boeing and scattergoodWebAug 2, 2012 · The results in these studies were ascribed to the activity of the liver receptor; however, our data raise the possibility that monocytes may contribute to the relevant physiological processes via the ASGPR. The findings have implications for the design of drugs targeting the liver via the ASGPR and drugs that are cleared by this receptor [29, … boeing and rolls royceWebAug 18, 2024 · Thyroid hormones (THs) along with their metabolites and thyroid hormone receptor β (THR-β) agonist are the main therapeutic targets. Other liver specific analogs and alternative treatments... boeing and pfizer donationsWebJun 16, 2024 · If hyperthyroidism isn't treated, it can cause some serious health problems, including: An irregular heartbeat that can lead to blood clots, stroke, heart failure, and … boeing and pfizer donated to republicansWebApr 7, 2015 · Thyroid hormone receptor (TR) agonists have been proposed as therapeutic agents to treat non-alcoholic fatty liver disease (NAFLD) and insulin resistance. We … boeing and saab tx trainer jetWebThis enhancement in hepatic LDL receptor expression results from about a 5-fold increase in the rate of transcription that occurs within 60 min after giving thyroid hormone to boeing and russian aluminumWebSep 25, 2007 · TR activation in the liver favorably affects plasma cholesterol and lipoprotein levels by multiple mechanisms, which may include increasing low-density lipoprotein clearance through increased … global basketball club