Glutathione s-transferase c-terminal domain
WebVariant 2 encodes a deduced 546-amino acid protein that lacks amino acids 55 to 141 of the full-length protein. GSTCD shares homology with glutatione S-transferases (GSTs; see 138359 ), but it lacks functional domains important for GST activity. Database analysis revealed ubiquitous GSTCD expression. WebNational Center for Biotechnology Information
Glutathione s-transferase c-terminal domain
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WebJan 24, 2024 · Castro-Caldas, M. et al. Glutathione S-transferase pi mediates MPTP-induced c-Jun N-terminal kinase activation in the nigrostriatal pathway. Mol. Neurobiol. 45 , 466–477 (2012). WebAug 8, 2011 · The plant glutathione S-transferase superfamily have been subdivided into eight classes. ... GSTs are 50-kDa homodimers with an α-helical C-terminal domain and a thioredoxin-folded N-terminal ...
WebApr 3, 2024 · Compared with the C-terminal domain sequences, the N-terminal domain sequences were much more conserved for ... Liu, Y. … WebThe Schistosoma juponicum 26 kDa glutathione S-transferase (sj26GST) consists of the N-terminal domain (N-domain), containing three alpha-helices (named H1-H3) and four …
WebDownload scientific diagram Identity values for the five hypothetical proteins in relation to glutathione S-transferase c-terminal domain. The values obtained from the predicted protein, the ... WebSep 15, 2024 · Pull-down analysis with glutathione S-transferase-fused SH2 and SH3 domains of Src and PI3-K demonstrated coprecipitation of L-plastin and TRAF-6 with the SH3 and SH2 domains of the PI3-K and Src proteins. However, the actual order of the interaction of proteins requires further elucidation; a comprehensive screening should …
The glutathione binding site, or "G-site", is located in the thioredoxin-like domain of both cytosolic and mitochondrial GSTs. The region containing the greatest amount of variability between the assorted classes is that of helix α2, where one of three different amino acid residues interacts with the glycine residue of glutathione. Two subgroups of cytosolic GSTs have been characterized based upon their interaction with glutathione: the Y-GST group, which uses a tyrosine residue to …
WebApr 1, 1999 · Glutathione S-transferase belongs to the system of ... The encoded proteins differ only for three amino acids all of them included in the C-terminal domain of the enzymes (R89P, E117K, I ... blast radius agencyWebGSTCD (glutathione S-transferase, C-terminal domain containing) is a 633 amino acid protein belonging to the GSTCD family and contains one GST C-terminal domain. The … frankenstein makeup prostheticWebBacterial glutathione transferases (GSTs; EC 2.5.1.18) are part of a superfamily of enzymes that play a crucial role in cellular detoxification. The primary role of GSTs is to catalyze the conjugation of glutathione (GSH) with the electrophilic centers of a wide variety of molecules. The most commonly known substrates of GSTs are xenobiotic synthetic … blast radius furry gameWebFeb 8, 2024 · An N-terminal domain containing the glutathione binding site and a C-terminal domain containing the 105 amino acids substrate binding site were present. ... The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Crit Rev Biochem Mol Biol. … frankenstein mapping the journeyWebGmGSTU23 and its homologs both contain an N-terminal domain (red line) and a C-terminal domain (blue line). (C) Prediction of the GmGSTU23 protein structure. The protein structure modeling template is [PDB c6ghfA]. One color represents one protein fold. ... The glutathione S-transferase gene has been isolated in a study in wild-type soybeans, ... frankenstein main charactersWebGSTCD (glutathione S-transferase, C-terminal domain containing) is a 633 amino acid protein belonging to the GSTCD family and contains one GST C-terminal domain. The gene encoding GSTCD maps to human chromosome 4, which represents approximately 6 % of the human genome and contains nearly 900 genes. Notably, the Huntingtin gene, … frankenstein mary shelley 1818 pdfWebGlutathione S-transferase, C-terminal domain is a structural domain of glutathione S-transferase . GST conjugates reduced glutathione to a variety of targets including S … frankenstein making the monster