Pml isoforms
WebRecruited into PML bodies together with CHEK2 (PubMed:12810724). Translocates to mitochondria upon oxidative stress (PubMed:22726440). Translocates to mitochondria in response to mitomycin C treatment (PubMed:27323408). .; ... Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs ... WebJul 1, 2024 · Structure of the PML gene and its splicing isoforms PML is a member of the tripartite motif (TRIM) family, which comprises proteins harboring a conserved N terminal motif formed by a RING finger, two B-boxes, and a coiled-coil domain (also called RBCC), and diverging C terminal domains [5 ].
Pml isoforms
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WebNov 3, 2006 · The PML gene encodes multiple isoforms, which are derived from alternative mRNA splicing. PML nuclear isoforms are localized in distinct subnuclear structures known as PML nuclear bodies (PML NBs), PML oncogenic domains (PODs), nuclear domain 10 (ND10), or Kremer (Kr) bodies WebDec 23, 2015 · Seven different PML isoforms have been described, all of which contain a TRIM motif but differ within their carboxyterminal sequences due to differential splicing. …
WebJan 10, 2024 · It is well recognized that promyelocytic leukemia (PML) proteins are scaffold molecules of PML-nuclear bodies (PML-NBs) in the nucleus and the generation of chimera proteins, PML-retinoic acid receptor α (PML-RARα), is involved in the pathogenesis of acute promyelocytic leukemia (APL) (de The et al. 2012; Shen et al. 2004 ). WebJul 1, 2024 · The promyelocytic leukemia protein isoform PML1 is an oncoprotein and a direct target of the antioxidant sulforaphane (SFN) Biochim. Biophys. Acta Mol. Cell Res. (2024) M. Chen Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism Nat. Commun. (2024) W.-C. Yuan
WebJul 2, 2024 · The requirement of promyelocytic leukaemia protein (PML) in interferon (IFN)-induced cell apoptosis is well-established. However, the exact mechanisms by which the multiple isoforms of PML protein participate in this process remain not well-understood. We previously demonstrated that PML isoform II (PML-II) positively regulates induced gene … WebJan 4, 2016 · The PML NB core is made of PML protein isoforms, which diverge in the C terminus because of alternative splicing (Bernardi and Pandolfi, 2007), and we found that PML isoform II (PML-II) plays a critical role in nuclear LD formation. The involvement of PML-II, however, was evident only in limited types of cells in which PML-II was targeted to ...
WebThere are six nuclear PML isoforms designated PMLI to PMLVI and one cytoplasmic isoform, PMLVIIb (called PMLVII in some publications) (Figure 1 B) ( Jensen et al., 2001 ). The isoforms are numbered in the inverse order of their size, PMLI being the longest and PMLVIIb the shortest.
WebNov 15, 2013 · To further study the role of specific PML isoforms and SATB1 in regulation of HLA gene expression, we inhibited PML-III, PML-V or SATB1 in L1236 by shRNA-based knockdown. The PML-III shRNA induced a ∼80% reduction at the PML-III mRNA level, but did not affect membranous HLA class I expression and possibly affected HLA class II … help for deep chest coughWebThe promyelocytic leukemia protein isoform PML1 is an oncoprotein and a direct target of the antioxidant sulforaphane (SFN). Dynamic PML protein nucleolar associations with … laminex white bardiglioWebMar 16, 2015 · In humans, at least seven PML isoforms (PML-I to PML-VII) are expressed by alternative splicing of a single pml gene. 42, 43 Transcription of this gene is tightly … help.ford.com-update-syncWebNov 2, 2024 · PML Antibody (E-11) is a mouse monoclonal IgG 1 κ PML antibody, cited in 20 publications, provided at 200 µg/ml; specific for an epitope mapping between amino acids 27-63 near the N-terminus of PML of human origin; PML Antibody (E-11) is recommended for detection of all isoforms of PML of mouse, rat and human origin by WB, IP, IF, IHC(P) … laminex white silkWebPML isoforms: a molecular basis for PML pleiotropic functions Highlights PML is a complex gene that undergoes extensive alternative splicing, leading to the formation of seven main … lamin familyWebJun 5, 2015 · The upper panel shows hDaxx expression levels in both cell types assessed by staining with an anti-hDaxx rabbit monoclonal antibody. The middle panels show detection of various SUMOylated as well as non-SUMOylated PML as well as Sp100 isoforms using anti-PML antibodies A301-167A/A301-168A and anti-Sp100 rabbit serum GH3, respectively. laming and wills ltdWebMultiple PML/RAR alpha isoforms and aberrant PML proteins were found to coexist in all APLs. These findings indicate that two potential oncogenic proteins are generated by the t(15;17) and suggest that the PML activation pathway is altered in APLs. Full text. help fordays.com