Traf2 and nck-interacting protein kinase
Splet31. mar. 2024 · We focussed on the novel interaction partner TRAF2- and NCK-interacting kinase TNIK, which is also associated with ID. Both CNK2 and TNIK are expressed in neuronal dendrites and concentrated in dendritic spines, and staining with synaptic markers indicates a clear postsynaptic localisation. SpletTraf2 is implicated in the regulation of c-Jun N-terminal kinase (JNK), a “stress-activated” MAPK, and the transcription factor NF-κB by TNF receptor or related receptors (for a review, see Ref. 26 ). Nck belongs to a family of adaptor proteins containing the Src homology (SH)2/SH3 domains.
Traf2 and nck-interacting protein kinase
Did you know?
Splet13. apr. 2024 · Mitogen-activated protein kinase (MAPK) cascades are crucial in extracellular signal transduction to cellular responses. The classical three-tiered MAPK cascades include signaling through MAP kinase kinase kinase (MAP3K) that activates a MAP kinase kinase (MAP2K), which in turn induces MAPK activation and downstream … Splet19. mar. 2016 · Traf2- and Nck-interacting kinase (TNIK), a serine/threonine kinase, is a member of the germinal center kinase (GCK) family. TNIK has an N-terminal kinase domain that was first identified as a regulator of cytoskeletal organization and cell spreading (Fu et al. 1999; Taira et al. 2004 ).
Splet09. apr. 2024 · We analyzed human NASH and normal liver tissue samples by RNA-Seq and LS/MS and identified hepatocyte cytosolic protein Myc-interacting zinc-finger protein 1 (Miz1) as a potential target in NASH progression. ... regulated by Parkin and PTEN-induced putative kinase protein 1 (PINK1) ... with the binding of Ubc13 to the RING domain of … SpletTraf2- and Nck-interacting kinase (TNIK; ref. 17) attracted our interest because various small-molecule kinase inhibi- tors have been applied successfully to cancer treatment
SpletGene ID: 100772764, updated on 28-May-2024. Summary Other designations. TRAF2 and NCK-interacting protein kinase, Traf2 and NCK-interacting protein kinase, Traf2 and … Splet09. nov. 2024 · TRAF2 and NCK-Interacting Kinase Inhibitors for Colorectal Cancer: In Vitro and Theoretical Validations TRAF2 and NCK-Interacting Kinase Inhibitors for Colorectal Cancer: In Vitro and Theoretical Validations ACS Comb Sci. 2024 Nov 9;22 (11):608-616. doi: 10.1021/acscombsci.0c00027. Epub 2024 Sep 29. Authors
Splet24. okt. 2015 · Prognostic significance of Traf2- and Nck- interacting kinase (TNIK) in colorectal cancer Authors Hidenori Takahashi 1 , Toshiaki Ishikawa 2 , Megumi Ishiguro 3 …
Splet01. avg. 2024 · The TRAF2 and NCK interacting kinase (TNIK) has been proposed to play a role in cytoskeletal organization and synaptic plasticity and has been linked, among … quotes about being holySplet24. okt. 2015 · In this study, we identified Traf2- and Nck-interacting kinase (TNIK) using microarray analysis as a candidate gene that was related to distant recurrence of CRC. TNIK is a member of the germinal center kinase family, and is reported to be essential for Wnt signaling and CRC proliferation and progression [10, 11]. However, the correlation ... quotes about being helpful to othersSplet15. jun. 2010 · We previously identified Traf2- and Nck-interacting kinase (TNIK) as one of the proteins that interact with TCF4 in colorectal cancer cells, but its functional … quotes about being hiddenSpletTRAF2 and NCK-interacting protein kinase is an enzyme that in humans is encoded by the TNIK gene. [5] [6] [7] Function [ edit] Germinal center kinases (GCKs), such as TNIK, are … shirley lane elementary bakersfieldSplet21. mar. 2024 · TRAF2 (TNF Receptor Associated Factor 2) is a Protein Coding gene. Diseases associated with TRAF2 include Lymphoma, Mucosa-Associated Lymphoid Type and Leukodystrophy, Hypomyelinating, 3 . Among its related pathways are MyD88 dependent cascade initiated on endosome and TNFR1 Pathway . shirley lane facebookSpletTnik TRAF2 and NCK interacting kinase [ (Norway rat)] Gene ID: 294917, updated on 24-Apr-2024 Summary Predicted to enable protein serine/threonine kinase activity. Involved in positive regulation of dendrite morphogenesis. Is active in glutamatergic synapse; postsynaptic density, intracellular component; and presynapse. shirley lanelle schleefSplet02. mar. 2024 · Title: Traf2- and Nck-interacting kinase (TNIK) is involved in the anti-cancer mechanism of dovitinib in human multiple myeloma IM-9 cells. Exome sequencing of … shirley lane obituary